Ketoconazole and miconazole alter potassium homeostasis in Saccharomyces cerevisiae

A Mathematical Model of the Potassium Homeostasis in Saccharomyces cerevisiae

Potassium and Rubidium Effluxes in Saccharomyces cerevisiae

M aría D . O rtega and A lonso Rodrí guez-N avarro Departamento de Microbiologfa, Escuela Tecnica Superior de Ingenieros Agrönomos, 14071 Cordoba, Spain Z. Naturforsch. 40c, 721 — 725 (1985); received May 22, 1985 Saccharomyces cerevisiae, Potassium Efflux, Rubidium Efflux, Potassium Transport, K+/K+ Exchange In growing cells, K+ and Rb+ effluxes followed first order kinetics, took place with s...

Genetic and environmental factors influencing glutathione homeostasis in Saccharomyces cerevisiae.

Glutathione is an essential metabolite protecting cells against oxidative stress and aging. Here, we show that endogenously synthesized glutathione undergoes intercellular cycling during growth to stationary phase. Genome-wide screening identified approximately 270 yeast deletion mutants that overexcrete glutathione, predominantly in the reduced form, and identified a surprising set of function...

Genomewide screening for genes involved in biofilm formation and miconazole susceptibility in Saccharomyces cerevisiae.

Infections related to fungal biofilms are difficult to treat due to the reduced susceptibility of sessile cells to most antifungal agents. Previous research has shown that 1-10% of sessile Candida cells survive treatment with high doses of miconazole (a fungicidal imidazole). The aim of this study was to identify genes involved in fungal biofilm formation and to unravel the mechanisms of resist...

Susceptibility of zygomycetes to amphotericin B, miconazole, and ketoconazole.

Susceptibility to amphotericin B, miconazole, and ketoconazole was determined for 25 clinical isolates of zygomycetes in yeast nitrogen base broth and human serum. In yeast nitrogen base broth, 7 of 25 isolates were susceptible to an imidazole or amphotericin B. In serum, all were resistant to the imidazoles and inhibited by amphotericin B, the current drug of choice for infections caused by zy...